CCDC88C

Across TCGA pan-cancer cohorts, CCDC88C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC88C data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CCDC88C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC88C expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where CCDC88C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.766	0.373	<.001	45	view →
PDAC	DFS	Tertile	III,IV	0.986	0.294	<.001	20	view →
LSCC	OS	Quartile	II,III,IV	0.902	0.589	.010	11	view →
UCEC	DFS	Median	II,III,IV	0.926	0.487	.004	8	view →
HNSC	OS	Tertile	III,IV	0.840	0.985	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC88C–CCRCC (DFS)

Open the CCRCC breakdown →