CCDC88C

Across TCGA pan-cancer cohorts, CCDC88C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CCDC88C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCDC88C RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC88C is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and STAD are the cancer types where CCDC88C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC88C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−2.219	<.001	10	view →
KIRC	All	II,III,IV	−0.369	.001	9	view →
STAD	Male	II,III,IV	+1.345	<.001	8	view →
KIRP	Male	All	−1.023	<.001	7	view →
THCA	Male	All	+0.975	.001	7	view →
HNSC	All	All	+0.697	<.001	7	view →
UCEC	All	All	+0.936	.006	6	view →
CHOL	All	II,III,IV	+2.630	<.001	4	view →
BRCA	All	All	+0.639	<.001	4	view →
COAD	Female	All	−0.544	<.001	4	view →
PRAD	All	All	+0.399	.003	2	view →
LUSC	All	All	+0.276	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CCDC88C–KICH

Open the KICH breakdown →