CCDC88C

Across TCGA patient cohorts, CCDC88C mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC88C-associated genes across cancer lineages are STAT3_pY705, C-Raf, and ATM. Each is linked with CCDC88C in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC88C-to-partner and partner-to-CCDC88C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CCDC88C-low versus CCDC88C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC88C→partner) and Y-score (partner→CCDC88C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STAT3_pY705 →	-0.247	-2.987	.028	.035	3	3
COAD	C-Raf →	+0.170	+3.204	.007	.008	3	3
UCEC	ATM →	-0.412	-2.379	<.001	<.001	3	3
STAD	Fibronectin →	+0.380	+3.190	.023	.009	3	2
UCEC	eIF4E →	+0.148	+1.750	.009	.003	3	2
UCEC	MEK1 →	+0.444	+1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

STAT3_pY705 by CCDC88C expression — COAD

Explore this box plot interactively →