CCDC87

Across TCGA patient cohorts, CCDC87 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC87-associated genes across cancer lineages are ERK2, JNK2, and MEK1. Each is linked with CCDC87 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC87-to-partner and partner-to-CCDC87 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CCDC87-low versus CCDC87-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC87→partner) and Y-score (partner→CCDC87) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.167	+1.415	.021	.046	3	2
UCEC	JNK2 →	+0.205	+2.169	.005	.003	3	2
UCEC	MEK1 →	+0.470	+2.906	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.129	-1.986	.021	.029	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.475	-2.222	.004	.010	3	2
UCEC	PCNA →	+0.206	+2.222	.010	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ERK2 by CCDC87 expression — UCEC

Explore this box plot interactively →