CCDC86

Across TCGA patient cohorts, CCDC86 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC86-associated genes across cancer lineages are FoxM1, ACVRL1, and mTOR_pS2448. Each is linked with CCDC86 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC86-to-partner and partner-to-CCDC86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CCDC86-low versus CCDC86-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC86→partner) and Y-score (partner→CCDC86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.248	+2.700	.033	.006	3	1
UCEC	ACVRL1 →	-0.161	-2.302	.008	.034	3	1
UCEC	mTOR_pS2448 →	-0.140	-3.150	.037	.019	3	1
UCEC	p27_pT198 →	+0.104	+2.000	.031	.032	3	1
UCEC	S6_pS240_S244 →	+0.553	+2.000	.002	.032	3	1
UCEC	STAT3_pY705 →	-0.433	-2.000	<.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by CCDC86 expression — UCEC

Explore this box plot interactively →