CCDC86

Across TCGA cell cohorts, CCDC86 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,484 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCDC86-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and DNA replication initiation. Each is linked with CCDC86 in more than 19 cancer types. Because this analysis shows association rather than direction, both CCDC86-to-partner and partner-to-CCDC86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by CCDC86-low versus CCDC86-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC86→partner) and Y-score (partner→CCDC86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.132	+1.459	<.001	<.001	3	20
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.176	+1.594	<.001	<.001	3	19
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.198	+1.302	.002	.003	3	19
BONE	rRNA processing →	+0.158	+1.285	<.001	<.001	3	19
LIVER	rRNA 5'-end processing →	+0.176	+1.594	<.001	<.001	3	19
KIDNEY	Mitotic spindle elongation →	+0.257	+0.783	.001	.002	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,484 associations by consensus.

Maturation of SSU-rRNA by CCDC86 expression — BLOOD_Lymphoma

Explore this box plot interactively →