CCDC85A

Across TCGA patient cohorts, CCDC85A mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC85A-associated genes across cancer lineages are HER3_pY1289, p38-MAPK_pT180_Y182, and Notch1. Each is linked with CCDC85A in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC85A-to-partner and partner-to-CCDC85A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by CCDC85A-low versus CCDC85A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC85A→partner) and Y-score (partner→CCDC85A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.059	+1.604	.019	.010	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.295	-1.045	.026	.038	3	3
UCEC	Notch1 →	+0.120	+1.920	.003	.008	3	2
UCEC	PCNA →	+0.207	+1.857	.001	<.001	3	2
UCEC	TIGAR →	+0.098	+1.085	.028	.025	3	2
UCEC	ATM →	-0.584	-2.099	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

HER3_pY1289 by CCDC85A expression — UCEC

Explore this box plot interactively →