CCDC81

Across TCGA patient cohorts, CCDC81 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC81-associated genes across cancer lineages are PDCD4, eIF4E, and FASN. Each is linked with CCDC81 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC81-to-partner and partner-to-CCDC81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CCDC81-low versus CCDC81-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC81→partner) and Y-score (partner→CCDC81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.502	-2.000	.003	.029	3	3
UCEC	eIF4E →	+0.200	+1.925	.008	.005	3	2
UCEC	FASN →	+0.335	+2.000	.018	.030	3	2
UCEC	ACVRL1 →	-0.122	-1.861	.012	.049	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.431	-1.571	.007	.019	3	2
UCEC	Shc_pY317 →	-0.218	-2.321	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PDCD4 by CCDC81 expression — UCEC

Explore this box plot interactively →