CCDC81

Across TCGA pan-cancer cohorts, CCDC81 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CCDC81’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC81 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC81 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and LUAD are the cancer types where CCDC81 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC81 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.767	<.001	11	view →
UCEC	All	All	−1.989	<.001	8	view →
LUAD	All	II,III,IV	−1.010	<.001	8	view →
LUSC	Male	II,III,IV	−0.948	<.001	7	view →
KIRC	Male	All	+0.253	<.001	7	view →
BLCA	All	IV	−0.287	.006	6	view →
LIHC	All	All	+0.093	<.001	5	view →
CHOL	All	All	+0.393	<.001	4	view →
PRAD	All	All	−0.327	<.001	2	view →
HNSC	Male	III,IV	+0.223	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CCDC81–THCA

Open the THCA breakdown →