CCDC8

Across TCGA pan-cancer cohorts, CCDC8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CCDC8 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CCDC8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC8 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where CCDC8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.682	0.958	<.001	29	view →
CCRCC	OS	Quartile	All	0.738	0.964	.005	11	view →
GBM	OS	Quartile	All	0.241	0.663	.015	9	view →
PDAC	OS	Tertile	IV	0.973	0.540	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CCDC8–LUAD (DFS)

Open the LUAD breakdown →