CCDC8

Across TCGA patient cohorts, CCDC8 protein abundance is significantly associated with the RNA expression of many other genes, with 11,230 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CCDC8-associated genes across cancer lineages are PNMA8A, MEOX2, and LOXL1. Each is linked with CCDC8 in more than 5 cancer types. Because this analysis shows association rather than direction, both CCDC8-to-partner and partner-to-CCDC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCDC8 versus PNMA8A in UCEC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC8→partner) and Y-score (partner→CCDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PNMA8A →	+1.593	+0.772	<.001	<.001	3	6
GBM	MEOX2 →	+1.471	+0.413	<.001	<.001	3	5
BRCA	LOXL1 →	+1.041	+0.612	<.001	<.001	3	5
BRCA	EFEMP2 →	+0.930	+0.700	<.001	<.001	3	5
BRCA	KANK2 →	+0.751	+0.586	<.001	<.001	3	5
OV	BTBD19 →	+1.346	+0.546	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,230 associations by consensus.

CCDC8 vs PNMA8A — UCEC

Explore this scatter interactively →