CCDC8

Across TCGA patient cohorts, CCDC8 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC8-associated genes across cancer lineages are ERK2, mTOR_pS2448, and PEA-15_pS116. Each is linked with CCDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC8-to-partner and partner-to-CCDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CCDC8-low versus CCDC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC8→partner) and Y-score (partner→CCDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.194	+2.321	.010	.033	3	2
UCEC	mTOR_pS2448 →	-0.200	-3.571	<.001	.002	3	2
UCEC	PEA-15_pS116 →	+0.331	+2.000	.016	.010	3	2
UCEC	C-Raf →	+0.147	+1.700	.009	.042	3	2
UCEC	EGFR_pY1068 →	-0.245	-1.584	.012	.036	3	1
UCEC	G6PD →	-0.281	-2.000	.026	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ERK2 by CCDC8 expression — UCEC

Explore this box plot interactively →