CCDC8

Across TCGA cell cohorts, CCDC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,149 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCDC8-associated GO terms across cancer lineages are Positive regulation of DNA metabolic process, Heterochromatin formation, and Positive regulation of DNA repair. Each is linked with CCDC8 in more than 8 cancer types. Because this analysis shows association rather than direction, both CCDC8-to-partner and partner-to-CCDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA metabolic process grouped by CCDC8-low versus CCDC8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC8→partner) and Y-score (partner→CCDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA metabolic process →	+0.079	+2.006	<.001	<.001	3	9
SOFT_TISSUE	Heterochromatin formation →	+0.061	+2.449	<.001	<.001	3	9
BONE	Positive regulation of DNA repair →	+0.083	+3.063	<.001	<.001	3	8
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.059	+3.030	<.001	<.001	3	8
OESOPHAGUS	Nucleic acid transport →	+0.121	+2.358	<.001	<.001	3	8
OESOPHAGUS	RNA transport →	+0.121	+2.358	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,149 associations by consensus.

Positive regulation of DNA metabolic process by CCDC8 expression — BONE

Explore this box plot interactively →