CCDC8

Across TCGA cell cohorts, CCDC8 mutation is significantly associated with the drug of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC8-associated genes across cancer lineages are AZD7762, Wee1 Inhibitor, and MK-1775. Each is linked with CCDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC8-to-partner and partner-to-CCDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD7762 grouped by CCDC8-low versus CCDC8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC8→partner) and Y-score (partner→CCDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD7762 →	+0.593	+2.868	.013	.022	3	1
LARGE_INTESTINE	Wee1 Inhibitor →	+0.568	+2.649	.031	.046	3	1
LARGE_INTESTINE	MK-1775 →	+0.312	+2.868	.044	.022	3	1
LARGE_INTESTINE	Cyclophosphamide →	+0.358	+2.649	.022	.046	3	1
LARGE_INTESTINE	AGI-6780 →	+0.441	+2.868	.015	.022	3	1
LARGE_INTESTINE	Sabutoclax →	+0.449	+2.991	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

AZD7762 by CCDC8 expression — LARGE_INTESTINE

Explore this box plot interactively →