CCDC74BP1

Across TCGA pan-cancer cohorts, CCDC74BP1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CCDC74BP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCDC74BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC74BP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LUSC, and KIRP are the cancer types where CCDC74BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC74BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.382	<.001	10	view →
LUSC	All	All	+0.229	.001	4	view →
KIRP	All	All	+0.057	.038	1	view →
THCA	All	All	−0.023	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CCDC74BP1–HNSC

Open the HNSC breakdown →