CCDC74B

Across TCGA patient cohorts, CCDC74B mutation is significantly associated with the RNA expression of many other genes, with 3,163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC74B-associated genes across cancer lineages are MIR4801, MIR4427, and RN7SL553P. Each is linked with CCDC74B in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC74B-to-partner and partner-to-CCDC74B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4801 grouped by CCDC74B-low versus CCDC74B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC74B→partner) and Y-score (partner→CCDC74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4801 →	+0.178	+4.351	<.001	.004	3	3
LUSC	MIR4427 →	+0.430	+2.760	.003	.006	3	3
BRCA	RN7SL553P →	+0.140	+5.442	<.001	.002	3	3
UCEC	CBARP →	+0.996	+3.392	<.001	<.001	3	3
UCEC	EDC3 →	+0.301	+1.869	.004	.005	3	2
UCEC	GEMIN4 →	+0.435	+2.757	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,163 associations by consensus.

MIR4801 by CCDC74B expression — SKCM

Explore this box plot interactively →