CCDC74B

Across TCGA pan-cancer cohorts, CCDC74B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CCDC74B data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CCDC74B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC74B expression acts as an unfavorable survival marker, although some lineages such as BRCA and CESC show a favorable association.

BLCA, BRCA, and KICH are the cancer types where CCDC74B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.306	0.509	<.001	115	view →
BRCA	OS	Median	All	0.954	0.893	<.001	114	view →
KICH	DFS	Median	All	0.656	1.000	.002	52	view →
ACC	DFS	Tertile	II,III,IV	0.460	0.770	.003	41	view →
CESC	OS	Median	II,III,IV	0.867	0.649	.001	38	view →
HNSC	OS	Tertile	All	0.463	0.787	<.001	37	view →
KIRC	OS	Quartile	All	0.532	0.725	<.001	34	view →
UCEC	OS	Quartile	All	0.973	0.901	.001	30	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	23	view →
ESCA	DFS	Median	II,III,IV	1.000	0.399	.013	15	view →
SKCM	OS	Tertile	All	0.852	0.907	.004	13	view →
LUAD	DFS	Tertile	All	0.272	0.449	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CCDC74B–BLCA (DFS)

Open the BLCA breakdown →