CCDC74B

Across TCGA patient cohorts, CCDC74B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC74B-associated genes across cancer lineages are ASNS, INPP4B, and JNK2. Each is linked with CCDC74B in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC74B-to-partner and partner-to-CCDC74B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CCDC74B-low versus CCDC74B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC74B→partner) and Y-score (partner→CCDC74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.520	+2.415	<.001	.003	3	3
UCEC	INPP4B →	-0.367	-2.807	.004	.003	3	2
UCEC	JNK2 →	+0.204	+2.331	.010	.019	3	2
UCEC	MEK1 →	+0.457	+2.906	.001	.001	3	2
UCEC	P-Cadherin →	-0.149	-3.459	.010	.005	3	2
UCEC	Src_pY527 →	-0.367	-2.999	.034	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by CCDC74B expression — UCEC

Explore this box plot interactively →