CCDC74A

Across TCGA patient cohorts, CCDC74A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC74A-associated genes across cancer lineages are NF2, A-Raf_pS299, and ACC_pS79. Each is linked with CCDC74A in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC74A-to-partner and partner-to-CCDC74A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by CCDC74A-low versus CCDC74A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC74A→partner) and Y-score (partner→CCDC74A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.258	+3.169	.008	.019	3	2
UCEC	A-Raf_pS299 →	-0.142	-3.169	.008	.019	3	1
UCEC	ACC_pS79 →	+0.366	+2.000	.019	.032	3	1
UCEC	JNK2 →	+0.254	+3.009	.004	.019	2	2
UCEC	Ku80 →	+0.305	+2.179	.004	.034	3	1
UCEC	p27_pT198 →	+0.096	+2.000	.046	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

NF2 by CCDC74A expression — UCEC

Explore this box plot interactively →