CCDC74A

Across TCGA pan-cancer cohorts, CCDC74A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CCDC74A data layer compared with 9 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CCDC74A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC74A expression acts as an unfavorable survival marker, although some lineages such as BRCA and MESO show a favorable association.

UVM, BRCA, and KICH are the cancer types where CCDC74A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.319	0.637	.001	97	view →
BRCA	OS	Tertile	II,III,IV	0.958	0.875	<.001	89	view →
KICH	OS	Tertile	All	0.581	1.000	.002	62	view →
KIRC	OS	Median	All	0.552	0.709	<.001	55	view →
MESO	OS	Tertile	All	0.748	0.281	.006	42	view →
BLCA	OS	Median	III,IV	0.257	0.458	.014	40	view →
CESC	OS	Tertile	All	0.836	0.692	.007	34	view →
LGG	OS	Tertile	All	0.739	0.883	<.001	29	view →
THCA	OS	Median	IV	0.578	0.939	.007	25	view →
LIHC	OS	Tertile	All	0.625	0.761	.011	18	view →
HNSC	DFS	Median	II,III,IV	0.669	0.548	.009	17	view →
LUAD	DFS	Median	All	0.281	0.414	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CCDC74A–UVM (DFS)

Open the UVM breakdown →