CCDC74A

Across TCGA cell cohorts, CCDC74A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC74A-associated genes across cancer lineages are UNCX, RBMY1A1, and GUCA2A. Each is linked with CCDC74A in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC74A-to-partner and partner-to-CCDC74A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNCX grouped by CCDC74A-low versus CCDC74A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC74A→partner) and Y-score (partner→CCDC74A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UNCX →	+0.036	+5.614	<.001	.002	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

UNCX by CCDC74A expression — PANCREAS

Explore this box plot interactively →