CCDC68

Across TCGA pan-cancer cohorts, CCDC68 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CCDC68 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CCDC68 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CCDC68 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where CCDC68 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.951	0.339	<.001	21	view →
PDAC	OS	Median	III,IV	0.720	0.213	.006	21	view →
LUAD	OS	Quartile	II,III,IV	0.293	0.715	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CCDC68–LSCC (OS)

Open the LSCC breakdown →