CCDC63

Across TCGA patient cohorts, CCDC63 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC63-associated genes across cancer lineages are Caspase-8, JNK_pT183_Y185, and MEK1. Each is linked with CCDC63 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC63-to-partner and partner-to-CCDC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by CCDC63-low versus CCDC63-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC63→partner) and Y-score (partner→CCDC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.242	-3.060	.003	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.148	-1.807	.008	.025	3	2
UCEC	MEK1 →	+0.334	+1.765	.006	.013	3	2
UCEC	CD49b →	-0.291	-2.787	.002	.003	3	2
SKCM	ACC_pS79 →	+0.263	+2.115	.020	.017	3	2
SKCM	IRS1 →	+0.174	+2.459	.003	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-8 by CCDC63 expression — UCEC

Explore this box plot interactively →