CCDC63

Across TCGA cell cohorts, CCDC63 mutation is significantly associated with the mutation status of many other genes, with 2,713 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC63-associated genes across cancer lineages are LIG1, CDH9, and NRXN2. Each is linked with CCDC63 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC63-to-partner and partner-to-CCDC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIG1 grouped by CCDC63-low versus CCDC63-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC63→partner) and Y-score (partner→CCDC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LIG1 →	+3.718	+4.266	<.001	<.001	1	4
LUNG_NSCLC_LUAD	CDH9 →	+2.718	+3.604	.003	.003	1	4
LARGE_INTESTINE	NRXN2 →	+1.959	+2.292	.003	.003	1	4
LUNG_SCLC	COL1A2 →	+2.985	+3.562	.008	.008	1	4
LARGE_INTESTINE	ZNF568 →	+1.959	+2.292	.003	.003	1	4
LARGE_INTESTINE	FBXO38 →	+3.000	+3.182	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,713 associations by consensus.

LIG1 by CCDC63 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →