CCDC57

Across TCGA cell cohorts, CCDC57 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC57-associated genes across cancer lineages are WNT8A, TBC1D21, and PYDC2. Each is linked with CCDC57 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC57-to-partner and partner-to-CCDC57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WNT8A grouped by CCDC57-low versus CCDC57-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC57→partner) and Y-score (partner→CCDC57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WNT8A →	+0.623	+3.893	.002	.001	3	2
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	CSN2 →	+0.045	+5.209	<.001	.005	3	1
CNS	IL27 →	+0.050	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

WNT8A by CCDC57 expression — BLOOD_Leukemia

Explore this box plot interactively →