CCDC54

Across TCGA patient cohorts, CCDC54 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC54-associated genes across cancer lineages are STAT3_pY705, Src, and HER2_pY1248. Each is linked with CCDC54 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC54-to-partner and partner-to-CCDC54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CCDC54-low versus CCDC54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC54→partner) and Y-score (partner→CCDC54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.365	-2.321	.002	.033	3	2
LUAD	Src →	+0.294	+2.819	.010	.035	3	1
SKCM	HER2_pY1248 →	+0.177	+3.169	.003	.017	3	1
SKCM	PDK1 →	+0.135	+3.000	.002	.034	3	1
SKCM	Annexin_VII →	+0.141	+2.186	.021	.032	3	1
UCEC	Ku80 →	+0.262	+1.887	.017	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

STAT3_pY705 by CCDC54 expression — UCEC

Explore this box plot interactively →