CCDC54

Across TCGA cell cohorts, CCDC54 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CCDC54-associated genes across cancer lineages are OR1M1, KRTAP21-2, and LEUTX. Each is linked with CCDC54 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC54-to-partner and partner-to-CCDC54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1M1 grouped by CCDC54-low versus CCDC54-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC54→partner) and Y-score (partner→CCDC54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1M1 →	+0.010	+4.058	<.001	.007	3	1
LUNG_SCLC	KRTAP21-2 →	+0.102	+4.169	<.001	.001	3	1
LUNG_SCLC	LEUTX →	+0.062	+3.817	<.001	.004	3	1
LUNG_SCLC	MBD3L2 →	+0.617	+3.523	<.001	.008	3	1
LUNG_SCLC	BLID →	+0.063	+3.523	<.001	.008	3	1
LUNG_SCLC	PRAMEF5 →	+0.039	+4.169	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR1M1 by CCDC54 expression — LUNG_SCLC

Explore this box plot interactively →