CCDC43

Across TCGA pan-cancer cohorts, CCDC43 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC43 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CCDC43 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC43 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, HNSC, and UCEC are the cancer types where CCDC43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.781	0.214	.002	20	view →
HNSC	DFS	Tertile	IV	0.531	0.752	.036	9	view →
UCEC	DFS	Median	All	1.000	0.936	.023	2	view →
PDAC	DFS	Median	III,IV	0.492	0.833	.041	1	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC43–LUAD (DFS)

Open the LUAD breakdown →