CCDC43

Across TCGA pan-cancer cohorts, CCDC43 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CCDC43’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCDC43 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC43 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where CCDC43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+0.790	<.001	12	view →
KIRC	Female	III,IV	+0.558	<.001	12	view →
BLCA	Male	All	+1.091	<.001	11	view →
KIRP	All	IV	+0.862	<.001	11	view →
LIHC	All	II,III,IV	+0.897	<.001	9	view →
STAD	Male	All	+0.818	<.001	9	view →
LUAD	Male	II,III,IV	+0.781	<.001	9	view →
KICH	Female	All	−1.058	<.001	7	view →
LUSC	Female	All	+0.663	<.001	6	view →
BRCA	All	III,IV	+0.661	<.001	6	view →
CHOL	Male	All	+2.508	<.001	5	view →
ESCA	All	All	+1.004	.005	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CCDC43–HNSC

Open the HNSC breakdown →