CCDC43

Across TCGA cell cohorts, CCDC43 mutation is significantly associated with the mutation status of many other genes, with 888 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC43-associated genes across cancer lineages are PHLDB1, PRDM11, and NCDN. Each is linked with CCDC43 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC43-to-partner and partner-to-CCDC43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHLDB1 grouped by CCDC43-low versus CCDC43-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC43→partner) and Y-score (partner→CCDC43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHLDB1 →	+2.284	+3.925	.005	.005	1	1
LARGE_INTESTINE	PRDM11 →	+3.007	+3.584	.008	.008	1	1
LARGE_INTESTINE	NCDN →	+2.744	+4.321	.002	.002	1	1
LARGE_INTESTINE	ADGRA2 →	+2.574	+4.182	.003	.003	1	1
LARGE_INTESTINE	GABRA1 →	+3.744	+4.044	.003	.003	1	1
LARGE_INTESTINE	RB1CC1 →	+2.744	+4.321	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 888 associations by consensus.

PHLDB1 by CCDC43 expression — LARGE_INTESTINE

Explore this box plot interactively →