CCDC40

Across TCGA patient cohorts, CCDC40 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC40-associated genes across cancer lineages are Caspase-7-cleavedD198, NDRG1_pT346, and PRAS40_pT246. Each is linked with CCDC40 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC40-to-partner and partner-to-CCDC40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC40-low versus CCDC40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC40→partner) and Y-score (partner→CCDC40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.622	+1.807	<.001	<.001	3	4
BLCA	NDRG1_pT346 →	-0.708	-3.169	.023	.019	3	3
UCEC	PRAS40_pT246 →	+0.122	+1.013	.017	.037	3	3
BLCA	mTOR →	+0.218	+3.187	.032	.010	3	2
UCEC	c-Met →	-0.185	-1.807	.038	<.001	3	2
STAD	ASNS →	+0.446	+3.321	.032	.010	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Caspase-7-cleavedD198 by CCDC40 expression — UCEC

Explore this box plot interactively →