CCDC40

Across TCGA pan-cancer cohorts, CCDC40 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CCDC40 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CCDC40 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC40 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

COAD, KIRC, and BRCA are the cancer types where CCDC40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.438	0.596	<.001	89	view →
KIRC	DFS	Tertile	All	0.539	0.708	<.001	82	view →
BRCA	OS	Median	III,IV	0.907	0.752	<.001	75	view →
ACC	DFS	Median	II,III,IV	0.478	0.767	.001	68	view →
LGG	DFS	Median	All	0.630	0.837	<.001	54	view →
BLCA	DFS	Median	All	0.209	0.483	.001	39	view →
PAAD	DFS	Tertile	All	0.557	0.350	<.001	39	view →
UCEC	OS	Tertile	All	0.761	0.580	.005	34	view →
LUAD	OS	Median	II,III,IV	0.342	0.126	<.001	31	view →
LIHC	DFS	Median	All	0.464	0.618	<.001	28	view →
PRAD	DFS	Median	All	0.905	0.960	.004	24	view →
UCS	DFS	Tertile	IV	0.956	0.510	.024	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CCDC40–COAD (DFS)

Open the COAD breakdown →