CCDC39

Across TCGA patient cohorts, CCDC39 mutation is significantly associated with the RNA expression of many other genes, with 5,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC39-associated genes across cancer lineages are RARS1, PRMT5, and HAT1. Each is linked with CCDC39 in more than 4 cancer types. Because this analysis shows association rather than direction, both CCDC39-to-partner and partner-to-CCDC39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RARS1 grouped by CCDC39-low versus CCDC39-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC39→partner) and Y-score (partner→CCDC39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RARS1 →	+0.373	+3.415	<.001	.004	3	5
UCEC	PRMT5 →	+0.521	+2.180	.001	.001	3	4
UCEC	HAT1 →	+0.563	+2.606	<.001	<.001	3	4
UCEC	MDH1 →	+0.339	+1.491	.001	<.001	3	4
UCEC	SUPV3L1 →	+0.293	+1.470	.001	<.001	3	4
UCEC	CDC23 →	+0.438	+2.000	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,825 associations by consensus.

RARS1 by CCDC39 expression — COAD

Explore this box plot interactively →