CCDC39

Across TCGA pan-cancer cohorts, CCDC39 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CCDC39’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC39 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC39 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where CCDC39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.860	<.001	10	view →
LUSC	Female	All	−0.892	<.001	8	view →
LUAD	All	III,IV	−0.882	<.001	7	view →
KICH	Female	All	−0.630	<.001	6	view →
LIHC	All	All	+0.090	.004	5	view →
UCEC	All	All	−1.225	<.001	4	view →
BRCA	Female	All	−0.310	<.001	4	view →
CHOL	All	All	+0.703	.004	2	view →
COAD	Female	II,III,IV	−0.205	.019	2	view →
KIRC	Female	IV	−0.303	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CCDC39–THCA

Open the THCA breakdown →