CCDC39

Across TCGA patient cohorts, CCDC39 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC39-associated genes across cancer lineages are XBP1, Cyclin-B1, and eIF4E. Each is linked with CCDC39 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC39-to-partner and partner-to-CCDC39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by CCDC39-low versus CCDC39-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC39→partner) and Y-score (partner→CCDC39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	-0.252	-3.000	.014	.034	3	3
UCEC	Cyclin-B1 →	+0.508	+1.347	.001	.006	3	3
UCEC	eIF4E →	+0.175	+2.247	.003	.001	3	3
UCEC	ATM →	-0.490	-2.489	<.001	.001	3	3
UCEC	VHL →	-0.639	-1.392	.001	.017	3	2
COAD	ASNS →	+0.561	+2.321	.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

XBP1 by CCDC39 expression — SKCM

Explore this box plot interactively →