CCDC39

Across TCGA cell cohorts, CCDC39 mutation is significantly associated with the RNA expression of many other genes, with 648 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC39-associated genes across cancer lineages are PCDH11Y, DAOA, and ADH5. Each is linked with CCDC39 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC39-to-partner and partner-to-CCDC39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by CCDC39-low versus CCDC39-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC39→partner) and Y-score (partner→CCDC39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	2
LUNG_NSCLC_LUAD	DAOA →	+0.017	+5.266	<.001	.001	3	2
LARGE_INTESTINE	ADH5 →	+0.625	+3.237	.001	.003	3	2
OVARY	GSC2 →	+0.143	+3.263	.001	.006	3	2
OESOPHAGUS	DYDC1 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 648 associations by consensus.

PCDH11Y by CCDC39 expression — URINARY_TRACT

Explore this box plot interactively →