CCDC38

Across TCGA patient cohorts, CCDC38 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC38-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and ERK2. Each is linked with CCDC38 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC38-to-partner and partner-to-CCDC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CCDC38-low versus CCDC38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC38→partner) and Y-score (partner→CCDC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+2.710	.003	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.688	+2.135	.003	.010	3	2
UCEC	ERK2 →	+0.189	+1.906	.014	.016	3	1
UCEC	JNK2 →	+0.195	+2.415	.014	.003	3	1
UCEC	MSH2 →	-0.288	-3.433	.001	.005	3	1
UCEC	p21 →	+0.172	+3.183	.026	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by CCDC38 expression — UCEC

Explore this box plot interactively →