CCDC33

Across TCGA patient cohorts, CCDC33 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC33-associated genes across cancer lineages are p62 Lck ligand, NF2, and MEK1. Each is linked with CCDC33 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC33-to-partner and partner-to-CCDC33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CCDC33-low versus CCDC33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC33→partner) and Y-score (partner→CCDC33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.483	+2.232	<.001	.005	3	3
LUSC	NF2 →	+0.254	+3.179	.017	.010	3	2
UCEC	MEK1 →	+0.489	+3.700	<.001	.001	3	2
UCEC	Paxillin →	+0.209	+1.502	.028	.030	3	2
SKCM	p90 RSK →	+0.186	+1.584	.023	.035	3	1
SKCM	SF2 →	+0.124	+2.492	.020	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p62 Lck ligand by CCDC33 expression — UCEC

Explore this box plot interactively →