CCDC3

Across TCGA patient cohorts, CCDC3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC3-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and mTOR_pS2448. Each is linked with CCDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC3-to-partner and partner-to-CCDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CCDC3-low versus CCDC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC3→partner) and Y-score (partner→CCDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.990	.045	.036	3	1
UCEC	GAPDH →	+0.613	+3.321	.029	.010	3	1
UCEC	mTOR_pS2448 →	-0.232	-3.308	.002	.009	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.666	-3.169	.004	.019	3	1
UCEC	PCNA →	+0.359	+3.000	.001	.036	2	2
UCEC	PKC-b-II_pS660 →	-0.385	-3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FOXO3a_pS318_S321 by CCDC3 expression — UCEC

Explore this box plot interactively →