CCDC3

Across TCGA pan-cancer cohorts, CCDC3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCDC3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCDC3 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and BLCA are the cancer types where CCDC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.813	<.001	11	view →
THCA	All	III,IV	−1.381	<.001	11	view →
BLCA	Male	All	−1.576	<.001	10	view →
KIRP	Female	All	−1.727	<.001	7	view →
COAD	All	II,III,IV	+0.669	<.001	7	view →
UCEC	All	III,IV	−3.213	<.001	6	view →
BRCA	All	All	−2.290	<.001	6	view →
HNSC	All	III,IV	+1.081	<.001	6	view →
LIHC	Male	All	−1.239	<.001	5	view →
PRAD	All	All	−1.069	<.001	2	view →
KIRC	Male	II,III,IV	−0.658	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CCDC3–KICH

Open the KICH breakdown →