CCDC27

Across TCGA patient cohorts, CCDC27 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC27-associated genes across cancer lineages are p27_pT198, Rad50, and S6_pS240_S244. Each is linked with CCDC27 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC27-to-partner and partner-to-CCDC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by CCDC27-low versus CCDC27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC27→partner) and Y-score (partner→CCDC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.084	+1.459	.015	.012	3	2
UCEC	Rad50 →	-0.184	-2.222	.019	.010	3	2
UCEC	S6_pS240_S244 →	+0.366	+3.000	.005	<.001	3	2
UCEC	Cyclin-B1 →	+0.512	+2.000	.004	.009	3	2
UCEC	EGFR_pY1068 →	-0.250	-2.169	.002	.003	3	1
UCEC	eIF4E →	+0.136	+1.584	.047	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

p27_pT198 by CCDC27 expression — UCEC

Explore this box plot interactively →