CCDC27

Across TCGA pan-cancer cohorts, CCDC27 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated CCDC27 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CCDC27 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC27 expression acts as an unfavorable survival marker, although some lineages such as UVM and THYM show a favorable association.

ACC, UVM, and UCEC are the cancer types where CCDC27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.412	0.809	<.001	105	view →
UVM	OS	Median	II,III,IV	0.802	0.374	<.001	98	view →
UCEC	DFS	Median	All	0.781	0.886	<.001	54	view →
LIHC	DFS	Tertile	All	0.202	0.327	.002	37	view →
KIRP	OS	Quartile	All	0.589	0.845	.002	32	view →
THCA	DFS	Median	III,IV	0.787	0.943	.012	27	view →
CESC	DFS	Quartile	All	0.736	0.850	.004	26	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	21	view →
STAD	OS	Quartile	III,IV	0.382	0.675	.017	16	view →
THYM	DFS	Median	All	0.934	0.799	.007	16	view →
BRCA	DFS	Tertile	III,IV	0.605	0.443	.006	14	view →
READ	OS	Tertile	II,III,IV	0.728	0.971	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

CCDC27–ACC (OS)

Open the ACC breakdown →