CCDC197

Across TCGA patient cohorts, CCDC197 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC197-associated genes across cancer lineages are MEK1, p62 Lck ligand, and PDK1_pS241. Each is linked with CCDC197 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC197-to-partner and partner-to-CCDC197 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CCDC197-low versus CCDC197-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC197→partner) and Y-score (partner→CCDC197) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.522	+2.459	.003	.019	3	1
UCEC	p62 Lck ligand →	+0.549	+3.179	<.001	.010	3	1
UCEC	PDK1_pS241 →	+0.203	+2.472	.014	.011	3	1
UCEC	Shc_pY317 →	-0.211	-3.000	.003	.036	3	1
UCEC	STAT3_pY705 →	-0.548	-3.584	<.001	.002	3	1
UCEC	Tuberin →	+0.402	+2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by CCDC197 expression — UCEC

Explore this box plot interactively →