CCDC191

Across TCGA patient cohorts, CCDC191 mutation is significantly associated with the RNA expression of many other genes, with 4,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC191-associated genes across cancer lineages are SKA1, THOP1, and ELAC2. Each is linked with CCDC191 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC191-to-partner and partner-to-CCDC191 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by CCDC191-low versus CCDC191-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC191→partner) and Y-score (partner→CCDC191) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.575	+1.885	<.001	<.001	3	3
UCEC	THOP1 →	+0.579	+2.332	<.001	<.001	3	3
UCEC	ELAC2 →	+0.404	+2.087	<.001	<.001	3	3
COAD	TBR1 →	+0.232	+3.195	<.001	.003	3	3
UCEC	CCDC134 →	+0.476	+2.839	<.001	<.001	3	3
UCEC	MCM5 →	+0.502	+1.740	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,098 associations by consensus.

SKA1 by CCDC191 expression — UCEC

Explore this box plot interactively →