CCDC191

Across TCGA pan-cancer cohorts, CCDC191 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CCDC191’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCDC191 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC191 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where CCDC191 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC191 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.050	<.001	11	view →
THCA	Male	All	−0.774	<.001	9	view →
LIHC	All	II,III,IV	+0.549	<.001	9	view →
CHOL	All	All	+2.493	<.001	5	view →
LUSC	All	II,III,IV	−0.649	.015	5	view →
LUAD	All	II,III,IV	−0.483	.008	5	view →
UCEC	All	All	−0.790	.003	2	view →
READ	All	III,IV	+0.299	.013	2	view →
COAD	Male	All	+0.288	.016	2	view →
BLCA	Female	III,IV	+0.839	.035	1	view →
HNSC	Male	III,IV	+0.486	.045	1	view →
KIRC	Male	II,III,IV	−0.260	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CCDC191–KICH

Open the KICH breakdown →