CCDC191

Across TCGA patient cohorts, CCDC191 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC191-associated genes across cancer lineages are ATM, Lck, and Akt_pT308. Each is linked with CCDC191 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC191-to-partner and partner-to-CCDC191 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CCDC191-low versus CCDC191-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC191→partner) and Y-score (partner→CCDC191) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.620	-1.857	<.001	<.001	3	3
UCEC	Lck →	+0.138	+1.058	.019	.037	3	2
UCEC	Akt_pT308 →	+0.419	+2.222	.024	.009	3	2
UCEC	P-Cadherin →	-0.089	-2.115	.035	.016	3	2
UCEC	PCNA →	+0.161	+1.637	.011	.001	3	2
UCEC	ASNS →	+0.341	+1.584	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by CCDC191 expression — UCEC

Explore this box plot interactively →