CCDC188

Across TCGA cell cohorts, CCDC188 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,137 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CCDC188-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Protein depolymerization, and Protein-containing complex disassembly. Each is linked with CCDC188 in more than 10 cancer types. Because this analysis shows association rather than direction, both CCDC188-to-partner and partner-to-CCDC188 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by CCDC188-low versus CCDC188-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC188→partner) and Y-score (partner→CCDC188) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.147	+0.585	.002	.008	3	11
SKIN	Protein depolymerization →	+0.120	+0.825	<.001	.003	3	10
SOFT_TISSUE	Protein-containing complex disassembly →	+0.076	+0.691	<.001	.001	3	10
SOFT_TISSUE	Establishment of Golgi localization →	+0.077	+0.476	.004	.007	3	10
SOFT_TISSUE	Positive regulation of intracellular protein transport →	+0.067	+0.624	<.001	.006	3	10
SKIN	Cytoplasmic microtubule organization →	+0.071	+1.485	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,137 associations by consensus.

Regulation of protein K48-linked ubiquitination by CCDC188 expression — UPPER_AERODIGESTIVE_TRACT

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