CCDC188

Across TCGA pan-cancer cohorts, CCDC188 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCDC188’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CCDC188 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC188 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LIHC, LUSC, and KIRC are the cancer types where CCDC188 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC188 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+0.298	<.001	8	view →
LUSC	All	II,III,IV	−0.753	<.001	7	view →
KIRC	All	All	+0.232	<.001	7	view →
BRCA	All	All	−0.689	<.001	6	view →
LUAD	Male	All	−0.634	<.001	6	view →
COAD	All	All	+0.280	.002	6	view →
KICH	All	All	−0.561	<.001	5	view →
KIRP	All	All	−0.385	.001	5	view →
UCEC	All	All	−0.513	.025	4	view →
STAD	Male	II,III,IV	+0.229	.026	2	view →
CHOL	All	All	+0.394	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CCDC188–LIHC

Open the LIHC breakdown →