CCDC186

Across TCGA pan-cancer cohorts, CCDC186 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC186 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CCDC186 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC186 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where CCDC186 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	1.000	0.848	.005	30	view →
LUAD	OS	Tertile	III,IV	0.848	0.331	.004	15	view →
HNSC	OS	Quartile	IV	1.000	0.774	.016	13	view →
CCRCC	DFS	Quartile	III,IV	0.489	0.860	.017	12	view →
PDAC	OS	Median	II,III,IV	0.946	0.717	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC186–UCEC (DFS)

Open the UCEC breakdown →