CCDC186

Across TCGA pan-cancer cohorts, CCDC186 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CCDC186’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCDC186 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC186 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where CCDC186 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC186 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.024	<.001	10	view →
THCA	All	II,III,IV	−0.692	<.001	8	view →
KIRP	Male	All	−0.731	<.001	6	view →
KICH	Male	All	−1.231	<.001	5	view →
COAD	Female	All	−0.907	<.001	4	view →
LUSC	Female	All	−0.687	.001	4	view →
CHOL	All	All	+1.403	.001	2	view →
UCEC	All	IV	−1.310	.039	2	view →
PRAD	All	All	+0.370	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CCDC186–KIRC

Open the KIRC breakdown →